Linked Life Data

2838851

Source:http://linkedlifedata.com/resource/pubmed/id/2838851

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1988-8-8
pubmed:abstractText
We investigated the in vivo effects of 1,25-dihydroxyvitamin D3, and serum calcium and inorganic phosphorus concentrations on productions of leukotriene B4 and 5-hydroxyeicosatetraenoic acid by glycogen stimulated peritoneal neutrophils of the rat. Neutrophils were incubated with ionophore A23187 for 5 min and the incubation medium was subjected to a reverse-phase high performance liquid chromatography for quantitation. Productions of these lipoxygenase metabolites by neutrophils from vitamin D depleted rats were decreased compared to the vitamin D sufficient levels. This difference was not observed when arachidonic acid was added to the incubation medium. When serum calcium concentrations of rats were altered by dietary calcium levels but 1,25-dihydroxyvitamin D3 was administered to those rats, the difference in serum calcium concentration did not show any effect on the production of leukotriene B4. In contrast, neutrophils from 1,25-dihydroxyvitamin D3 sufficient but phosphorus deficient rats still demonstrated decreased leukotriene B4 production. This reduction was corrected by exogenous arachidonic acid. The data suggest that 1,25-dihydroxyvitamin D3 or cellular calcium translocation mediated by the hormone, and serum inorganic phosphorus independent of 1,25-dihydroxyvitamin D3 affect arachidonic acid release, thus productions of leukotriene B4 and 5-hydroxyeicosatetraenoic acid.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0952-3278
pubmed:author
pubmed:issnType
Print
pubmed:volume
32
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
9-14
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1988
pubmed:articleTitle
In vivo effects of 1,25-dihydroxyvitamin D3 and minerals on synthesis of leukotriene B4 and 5-hydroxyeicosatetraenoic acid by rat peritoneal neutrophils.
pubmed:affiliation
Veterans Administration Medical Center, Albany, New York.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, Non-P.H.S.