Linked Life Data

2838832

Source:http://linkedlifedata.com/resource/pubmed/id/2838832

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1988-8-8
pubmed:abstractText
Polyoxyethylene alkylphenols (PA) are a group of non-ionic surfactants with a widespread use. As part of the safety evaluation of PA a teratology study with nonoxynol-9 and -30 (NP-9 and NP-30) administered perorally and epicutaneously to rats was performed. In addition the mutagenicity of NP-9 was tested in the Ames test. Treatment of pregnant rats with NP-30 (up to 1 g/kg b.wt./day, orally) did not reveal any signs of adverse effects. Pregnant rats given 250 mg or 500 mg NP-9/kg b.wt./day orally exhibited a statistically significant decrease in weight gain. A concomitant effect in these dams on reproduction, and an increase in the incidence of extra ribs and dilated pelvic cavity in their foetuses was interpreted as a consequence of a toxic effect of high doses of NP-9. No clear cut effect was observed when pregnant rats were dosed epicutaneously with up to 500 mg of NP-9/kg b.wt./day. A slight but persistent response in one tester strain in the Ames test was not interpreted as a clear mutagenic effect of NP-9.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0901-9928
pubmed:author
pubmed:issnType
Print
pubmed:volume
62
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
236-8
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1988
pubmed:articleTitle
Teratogenicity and in vitro mutagenicity studies on nonoxynol-9 and -30.
pubmed:affiliation
National Food Agency, Institute of Toxicology, Søborg, Denmark.
pubmed:publicationType
Journal Article