Linked Life Data

2836035

Source:http://linkedlifedata.com/resource/pubmed/id/2836035

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1988-6-30
pubmed:abstractText
Atrial natriuretic factor (ANF)-responding, cyclic guanosine monophosphate (cGMP)-producing cells were visualized in the hippocampus of the rat applying cGMP immunocytochemistry to hippocampal tissue slices incubated in vitro. These cells were found scattered throughout the hippocampus with their highest density in the hilus fascia dentata. Staining with an antibody against glial fibrillary acidic protein showed a completely different pattern, suggesting a non-glial nature of the ANF-responding cells. cGMP accumulation assayed biochemically was observed already at 10 microM ANF and was sensitive to inhibition by Methylene blue. The immunocytochemical data were fully supported by the biochemical measurements of cGMP under these conditions. Our results show for the first time a response to ANF of individual, cGMP-producing cells in the CNS of the rat.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0006-8993
pubmed:author
pubmed:issnType
Print
pubmed:day
19
pubmed:volume
446
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
387-95
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1988
pubmed:articleTitle
Atrial natriuretic factor-responding and cyclic guanosine monophosphate (cGMP)-producing cells in the rat hippocampus: a combined micropharmacological and immunocytochemical approach.
pubmed:affiliation
Department of Pharmacology, Faculty of Medicine, Free University, Amsterdam, The Netherlands.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't