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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
1988-6-16
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pubmed:abstractText |
The recent molecular cloning of the complementary DNA encoding T cell--replacing factor (TRF) has demonstrated that a single molecule is responsible for B cell growth factor II (BCGF-II) activity and eosinophil differentiation activity. It has been proposed that this molecule be called interleukin 5 (IL-5). We previously reported that purified rIL-5 supports the terminal differentiation and proliferation of eosinophilic precursors. In this study, we examined the effects of IL-5 on functional activities of mature eosinophils. IL-5 maintained the viability of mature eosinophils obtained from peritoneal exudate cells of mice infected with parasites. It also induced superoxide anion production in a dose-dependent manner. The Boyden's chamber Millipore assay revealed that IL-5 had a marked chemokinetic effect on eosinophils in a dose-dependent manner. Moreover, IL-5 was found to be an eosinophil chemotactic factor by the checkerboard assay. In conclusion, IL-5 is suggested to play an important role in increasing the functional activities of eosinophils as well as their production in allergic and parasitic diseases.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/2835420-13930964,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2835420-14316948,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2835420-2440025,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2835420-2823259,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2835420-3110787,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2835420-3257253,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2835420-3484551,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2835420-3484805,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2835420-3495002,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2835420-3871109,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2835420-3872907,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2835420-3902470,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2835420-4568301,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2835420-4697835,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2835420-4822532,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2835420-6159416,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2835420-6322187,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2835420-909604
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0022-1007
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
167
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1737-42
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:2835420-Animals,
pubmed-meshheading:2835420-Cell Survival,
pubmed-meshheading:2835420-Cells, Cultured,
pubmed-meshheading:2835420-Chemotactic Factors,
pubmed-meshheading:2835420-Eosinophils,
pubmed-meshheading:2835420-Female,
pubmed-meshheading:2835420-Interleukin-5,
pubmed-meshheading:2835420-Interleukins,
pubmed-meshheading:2835420-Mice,
pubmed-meshheading:2835420-Mice, Inbred BALB C,
pubmed-meshheading:2835420-Recombinant Proteins,
pubmed-meshheading:2835420-Superoxides
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pubmed:year |
1988
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pubmed:articleTitle |
Highly purified murine interleukin 5 (IL-5) stimulates eosinophil function and prolongs in vitro survival. IL-5 as an eosinophil chemotactic factor.
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pubmed:affiliation |
Department of Medicine, Jichi Medical School, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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