Linked Life Data

2835154

Source:http://linkedlifedata.com/resource/pubmed/id/2835154

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
11
pubmed:dateCreated
1988-6-15
pubmed:abstractText
Normal and diseased human tissues were analyzed for the transcription of genes of the carcinoembryonic (CEA) family. Epithelial tissues of colonic origin, whether malignant or normal, all express two closely related mRNA species of 3.0- and 3.5-kilobase mRNA which code for CEA. Only tissues of colonic origin were found to express these CEA-specific transcripts. Colon carcinomas consistently express a 2.6-kilobase mRNA species as well which codes for nonspecific cross-reacting antigen. Nonneoplastic colon mucosas, on the other hand, express lower or nondetectable levels of this transcript. Most breast carcinomas produce only the nonspecific cross-reacting antigen mRNA, whereas leukocytes of chronic myelogeneous leukemia express both nonspecific cross-reacting antigen mRNA and a 2.3-kilobase mRNA corresponding to a yet undefined gene of the CEA family. Thus the multiple CEA-like products reported to be produced by these tissues correspond to only four different mRNA species coding for three different peptides. These data suggest a less complex organization of the CEA family than was previously suspected and point to posttranscriptional modifications, such as variable patterns of glycosylation, as the likely reason for much of the observed complexity in CEA-like glycoproteins.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0008-5472
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
48
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
3153-7
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1988
pubmed:articleTitle
Transcription of genes of the carcinoembryonic antigen family in malignant and nonmalignant human tissues.
pubmed:affiliation
Department of Biochemistry, McGill University, Montreal, Quebec, Canada.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't