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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
1988-6-9
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pubmed:abstractText |
The effects of melanin on the iron-catalyzed decomposition of hydrogen peroxide to hydroxyl radicals and hydroxyl ions have been studied using electron spin resonance, spin trapping and visible light spectrophotometry. Melanin altered these reactions by several different mechanisms and consequently, depending on conditions, can significantly increase or decrease the yield of reactive products, including hydroxyl radicals. For low concentrations of ferrous ions, melanin decreased the yield of hydroxyl radicals due to binding of ferrous ions by melanin; ferrous ions bound to melanin did not decompose H2O2 efficiently. Melanins increased the rate of hydroxyl radical production if the predominant form of iron was ferric, due to the ability of melanin to reduce ferric to ferrous iron. Hydroxyl radical production in the presence of a strong chelator (e.g. EDTA) and melanin was greater than in the presence of a weak chelator (e.g. ADP) and melanin. Melanin also increased the rate of destruction of the DMPO-OH adduct.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/5,5-dimethyl-1-pyrroline-1-oxide,
http://linkedlifedata.com/resource/pubmed/chemical/Adenosine Diphosphate,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclic N-Oxides,
http://linkedlifedata.com/resource/pubmed/chemical/Edetic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/Ferric Compounds,
http://linkedlifedata.com/resource/pubmed/chemical/Ferrous Compounds,
http://linkedlifedata.com/resource/pubmed/chemical/Hydrogen Peroxide,
http://linkedlifedata.com/resource/pubmed/chemical/Hydroxides,
http://linkedlifedata.com/resource/pubmed/chemical/Hydroxyl Radical,
http://linkedlifedata.com/resource/pubmed/chemical/Iron,
http://linkedlifedata.com/resource/pubmed/chemical/Melanins,
http://linkedlifedata.com/resource/pubmed/chemical/Spin Labels
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pubmed:status |
MEDLINE
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pubmed:issn |
0891-5849
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
4
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
285-93
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:2834276-Adenosine Diphosphate,
pubmed-meshheading:2834276-Cyclic N-Oxides,
pubmed-meshheading:2834276-Edetic Acid,
pubmed-meshheading:2834276-Electron Spin Resonance Spectroscopy,
pubmed-meshheading:2834276-Ferric Compounds,
pubmed-meshheading:2834276-Ferrous Compounds,
pubmed-meshheading:2834276-Hydrogen Peroxide,
pubmed-meshheading:2834276-Hydroxides,
pubmed-meshheading:2834276-Hydroxyl Radical,
pubmed-meshheading:2834276-Iron,
pubmed-meshheading:2834276-Kinetics,
pubmed-meshheading:2834276-Melanins,
pubmed-meshheading:2834276-Oxidation-Reduction,
pubmed-meshheading:2834276-Spectrophotometry,
pubmed-meshheading:2834276-Spin Labels
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pubmed:year |
1988
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pubmed:articleTitle |
The effect of melanin on iron associated decomposition of hydrogen peroxide.
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pubmed:affiliation |
Department of Biophysics, Jagiellonian University, Krakow, Poland.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
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