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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1988-6-1
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pubmed:abstractText |
Interactions of protein kinase C (PKC) and cAMP-dependent protein kinase (PKA) systems were investigated in HL60 cells. It was found that the differentiating effects of 12-O-tetradecanoylphorbol-13-acetate (TPA) were potentiated by dibutyryl cAMP (dbcAMP) or prostaglandin E2 (PGE2). In addition, dbcAMP or PGE2 inhibited TPA-induced binding of PKC to plasma membrane, leading to decreased protein phosphorylation, and promoted subsequent redistribution of enzyme to the nuclear membrane region. The findings are consistent with the hypothesis that PKC and PKA systems regulate cooperatively the phenotypical differentiation of leukemic cells.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0014-5793
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
25
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pubmed:volume |
231
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
407-12
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:2834235-Biological Transport,
pubmed-meshheading:2834235-Bucladesine,
pubmed-meshheading:2834235-Cell Differentiation,
pubmed-meshheading:2834235-Dinoprostone,
pubmed-meshheading:2834235-Drug Synergism,
pubmed-meshheading:2834235-Humans,
pubmed-meshheading:2834235-Leukemia, Myeloid, Acute,
pubmed-meshheading:2834235-Male,
pubmed-meshheading:2834235-Membrane Proteins,
pubmed-meshheading:2834235-Middle Aged,
pubmed-meshheading:2834235-Neoplasm Proteins,
pubmed-meshheading:2834235-Phosphorylation,
pubmed-meshheading:2834235-Prostaglandins E,
pubmed-meshheading:2834235-Protein Kinase C,
pubmed-meshheading:2834235-Protein Kinases,
pubmed-meshheading:2834235-Tetradecanoylphorbol Acetate,
pubmed-meshheading:2834235-Tumor Cells, Cultured
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pubmed:year |
1988
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pubmed:articleTitle |
Cooperative interactions of protein kinase C and cAMP-dependent protein kinase systems in human promyelocytic leukemia HL60 cells.
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pubmed:affiliation |
Department of Pharmacology, Emory University School of Medicine, Atlanta, GA 30322.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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