Linked Life Data

2832870

Source:http://linkedlifedata.com/resource/pubmed/id/2832870

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1988-5-3
pubmed:abstractText
The behavioral consequences of prolonged continuous exposure to cocaine were examined in rhesus monkeys. Operant behavior was sampled for 0.5 h every 6 h, and cocaine was continuously infused through an intravenous catheter. Cocaine (4.0-32 mg/kg/day) initially caused reductions in the rate of responding for food and tolerance developed to this effect. When the infusion of cocaine was terminated following a period of exposure during which cocaine dose was escalated to 32 mg/kg/day, there was a marked suppression of operant behavior, lasting as long as 72 h, as well as observable changes in behavior (e.g., hyporesponsiveness). This is the first demonstration of behavioral disruptions following discontinuation of cocaine exposure and suggests that the preparation will be a useful animal model for further examining the possibility that exposure to cocaine can induce dependence.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0033-3158
pubmed:author
pubmed:issnType
Print
pubmed:volume
94
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
288-91
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1988
pubmed:articleTitle
Evidence for cocaine dependence in monkeys following a prolonged period of exposure.
pubmed:affiliation
Department of Psychiatry, Pritzker School of Medicine, University of Chicago, IL 60637.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.