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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1988-5-10
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pubmed:abstractText |
Using frogs treated 1 month with prednisolone, we studied responses of the muscle postjunctional membrane to acetylcholine and carbamylcholine. In control muscles following a bath application of 3 microM neostigmine or 30 microM pyridostigmine, there was an increased depolarization response to iontophoretically applied acetylcholine or carbamylcholine. Results with prednisolone-treated frog muscle were essentially identical. In some fibers of prednisolone-treated muscle there was a decrementing response to repetitive iontophoretic application of carbamylcholine. Prolonged administration of prednisolone may accelerate desensitization of acetylcholine receptors during repetitive application of agonist.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0148-639X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
11
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
265-9
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:2832755-Acetylcholine,
pubmed-meshheading:2832755-Animals,
pubmed-meshheading:2832755-Carbachol,
pubmed-meshheading:2832755-Neostigmine,
pubmed-meshheading:2832755-Neuromuscular Junction,
pubmed-meshheading:2832755-Prednisolone,
pubmed-meshheading:2832755-Pyridostigmine Bromide,
pubmed-meshheading:2832755-Rana pipiens,
pubmed-meshheading:2832755-Receptors, Cholinergic,
pubmed-meshheading:2832755-Synaptic Transmission,
pubmed-meshheading:2832755-Time Factors
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pubmed:year |
1988
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pubmed:articleTitle |
Effects of chronic prednisolone treatment on postjunctional membrane responses to agonist.
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pubmed:affiliation |
Department of Physiology, Columbia University, New York, NY.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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