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rdf:type |
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lifeskim:mentions |
umls-concept:C0017262,
umls-concept:C0020792,
umls-concept:C0086418,
umls-concept:C0185117,
umls-concept:C0439851,
umls-concept:C0449774,
umls-concept:C0728938,
umls-concept:C0753627,
umls-concept:C1173313,
umls-concept:C1552596,
umls-concept:C1705582,
umls-concept:C1836606,
umls-concept:C1947931,
umls-concept:C1998793,
umls-concept:C2243049,
umls-concept:C2911684
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pubmed:issue |
3
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pubmed:dateCreated |
1988-5-2
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pubmed:abstractText |
IL-2 binds to high- and low-affinity receptors on activated T cells. The high-affinity receptor was hypothesized to consist of the noncovalent association between the alpha chain (IL-2-R-alpha, p55) and a beta chain (IL-2-R-beta, p70), whereas the low-affinity receptor consists of p55 without p70. We now directly identify p70 as a 65-77-kD glycoprotein doublet. Preparative quantities of the IL-2/p70 complex have been isolated. Further, we demonstrate that p70 is the principal IL-2 binding protein on both resting CD4+ and CD8+ T cells and that both p70 and p55 can be induced on normal B cells and monocytes.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/2832509-2578514,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2832509-3019569,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2832509-3081898,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2832509-3095922,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2832509-3098894,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2832509-3099289,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2832509-3108674,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2832509-3114379,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2832509-3878228,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2832509-3928803,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2832509-6090574,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2832509-6092511,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2832509-6203980,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2832509-6413638,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2832509-6417659,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2832509-6815536
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0022-1007
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
167
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1265-70
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:2832509-Antigens, CD27,
pubmed-meshheading:2832509-Antigens, Surface,
pubmed-meshheading:2832509-B-Lymphocytes,
pubmed-meshheading:2832509-Gene Expression Regulation,
pubmed-meshheading:2832509-Glycoproteins,
pubmed-meshheading:2832509-Humans,
pubmed-meshheading:2832509-Interleukin-2,
pubmed-meshheading:2832509-Leukocytes, Mononuclear,
pubmed-meshheading:2832509-Lymphocyte Activation,
pubmed-meshheading:2832509-Molecular Weight,
pubmed-meshheading:2832509-Receptors, Immunologic,
pubmed-meshheading:2832509-Receptors, Interleukin-2,
pubmed-meshheading:2832509-T-Lymphocytes,
pubmed-meshheading:2832509-Tumor Cells, Cultured
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pubmed:year |
1988
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pubmed:articleTitle |
The human interleukin 2 receptor beta chain (p70). Direct identification, partial purification, and patterns of expression on peripheral blood mononuclear cells.
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pubmed:affiliation |
Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development, Bethesda, Maryland 20892.
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pubmed:publicationType |
Journal Article
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