Linked Life Data

2832296

Source:http://linkedlifedata.com/resource/pubmed/id/2832296

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1988-5-10
pubmed:abstractText
The value of CRH as a diagnostic and heuristic tool in hypothalamic-pituitary diseases is discussed. Biochemical and clinical data support the concept that a single bolus injection of CRH can divide patients with secondary adrenal failure into those with hypothalamic and those with pituitary disease. The results of CRH tests in patients with isolated ACTH deficiency suggest a pituitary defect in the majority of patients with this rare disorder. CRH administration in patients with acromegaly and macroprolactinoma demonstrates that the response of the pituitary to CRH is not modulated by high levels of growth hormone or prolactin. CRH can also be used to study the type of the secondary adrenal failure due to exogenous administration of glucocorticoids or endogenous overproduction of cortisol by an adrenal adenoma. The CRH-ACTH axis in man is a highly conserved system with unique characteristics which are a prerequisite to assure vitally important stress reactions.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0170-5903
pubmed:author
pubmed:issnType
Print
pubmed:volume
16
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
68-73
pubmed:dateRevised
2007-7-23
pubmed:meshHeading
pubmed:year
1987
pubmed:articleTitle
CRH as a diagnostic and heuristic tool in hypothalamic-pituitary diseases.
pubmed:affiliation
Department of Medicine, Sint Radboud Hospital, University of Nijmegen, The Netherlands.
pubmed:publicationType
Journal Article, Review