Linked Life Data

2831857

Source:http://linkedlifedata.com/resource/pubmed/id/2831857

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3-4
pubmed:dateCreated
1988-4-15
pubmed:abstractText
Persistent infections with Sendai and SSPE virus were established in Vero cells. Sequential passages of these cells were monitored by immunofluorescence and for their sensitivity to the antiviral and antiproliferative effects of interferon (IFN). The cells rapidly developed resistance to the antiviral effect of IFN as judged by the inability of IFN to inhibit the replication of exogenous Sindbis virus. This decrease was accompanied by a reduction in the induction of the 2'-5' oligo A synthetase. Both cell lines were resistant to the antiproliferative effect of IFN. A decrease or absence of IFN receptors on the surface of the cells was not found to be the cause of their resistance to IFN.
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0304-8608
pubmed:author
pubmed:issnType
Print
pubmed:volume
98
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
235-51
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed-meshheading:2831857-2',5'-Oligoadenylate Synthetase, pubmed-meshheading:2831857-Animals, pubmed-meshheading:2831857-Cell Division, pubmed-meshheading:2831857-Drug Resistance, Microbial, pubmed-meshheading:2831857-Eukaryotic Initiation Factor-2, pubmed-meshheading:2831857-Interferon Type I, pubmed-meshheading:2831857-Parainfluenza Virus 1, Human, pubmed-meshheading:2831857-Peptide Initiation Factors, pubmed-meshheading:2831857-Phosphorylation, pubmed-meshheading:2831857-Protein Kinases, pubmed-meshheading:2831857-Proteins, pubmed-meshheading:2831857-Receptors, Immunologic, pubmed-meshheading:2831857-Receptors, Interferon, pubmed-meshheading:2831857-SSPE Virus, pubmed-meshheading:2831857-Sindbis Virus, pubmed-meshheading:2831857-Vero Cells, pubmed-meshheading:2831857-Virus Replication
pubmed:year
1988
pubmed:articleTitle
Effect of interferon on Vero cells persistently infected with Sendai virus compared to Vero cells persistently infected with SSPE virus.
pubmed:affiliation
National Institute for Virology, Sandringham, South Africa.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't