Linked Life Data

2831286

Source:http://linkedlifedata.com/resource/pubmed/id/2831286

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1988-4-21
pubmed:abstractText
Marked neutropenia, complete depletion of the neutrophil storage pool, and death within 48 h were observed in newborn rats intrapulmonically inoculated with 10(5) type III group B streptococci (GBS). Intraperitoneal administration of 225 mg of intravenous human immune globulin (IVIG) immediately after intrapulmonic inoculation of GBS significantly lessened the degree of neutropenia and prevented depletion of the neutrophil storage pool and death. No effect of IVIG on neutrophil production was observed in vitro, in cultures of granulocytic progenitor cells, or in vivo, as assessed by quantifying circulating and storage pools in normal neonatal rats injected with IVIG. IVIG, however, markedly hastened release of neutrophils from the reserves into the blood and hastened the arrival of neutrophils at the site of the bacterial injection (the right lung). Specific antibody to GBS, as opposed to a nonspecific IgG effect, appeared to be responsible for the improvements in neutrophils kinetics and for survival of the animals.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0022-1899
pubmed:author
pubmed:issnType
Print
pubmed:volume
157
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
705-12
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1988
pubmed:articleTitle
Circulating and storage neutrophils in septic neonatal rats treated with immune globulin.
pubmed:affiliation
Division of Human Development and Aging, University of Utah School of Medicine, Salt Lake City 81432.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.