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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
1988-3-28
|
| pubmed:abstractText |
Though minor sequence differences between-species have been reported for adrenocorticotrophin, ACTH(1-39), the steroidogenic moiety ACTH(1-24) has appeared invariant in mammals. We here report the isolation, purification and amino acid sequencing of guinea-pig (GP) ACTH in which Pro24 is replaced by Ala24, and the demonstration that GP-ACTH stimulates aldosterone production to maximal levels well above those seen with human ACTH(1-39) or Synacthen, ACTH(1-24) amide, the synthetic ACTH fragment widely used for diagnostic and therapeutic purposes.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Nov
|
| pubmed:issn |
0022-0795
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
115
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
R5-8
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:2830360-Adrenal Cortex,
pubmed-meshheading:2830360-Adrenocorticotropic Hormone,
pubmed-meshheading:2830360-Aldosterone,
pubmed-meshheading:2830360-Amino Acid Sequence,
pubmed-meshheading:2830360-Animals,
pubmed-meshheading:2830360-Guinea Pigs,
pubmed-meshheading:2830360-Molecular Sequence Data
|
| pubmed:year |
1987
|
| pubmed:articleTitle |
Isolation, amino acid sequence and action of guinea-pig ACTH on aldosterone production by glomerulosa cells.
|
| pubmed:affiliation |
Medical Research Centre, Prince Henry's Hospital, Melbourne, Australia.
|
| pubmed:publicationType |
Journal Article
|