Linked Life Data

2829700

Source:http://linkedlifedata.com/resource/pubmed/id/2829700

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1988-3-15
pubmed:abstractText
The prenatal ontogeny of several receptor sites is reviewed. Binding sites for nicotine are found in fetal rat brain from gestational day 14; their regional development is described. Prenatal nicotine exposure interferes with the organization of the gonadal axis of the male rat fetus and is followed by permanent alterations in catecholamine metabolite levels. Cannabis, ethanol, barbiturates and opiates are also capable of disturbing the sexual differentiation of the central nervous system. These observations indicate that interactions with the ontogeny of neuroendocrine systems represent an important pathogenetic mechanism through which drugs can affect brain development. Recent observations on receptor development in the human fetus suggest the existence of a comparable sensitive period.
pubmed:language
fre
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0003-4266
pubmed:author
pubmed:issnType
Print
pubmed:volume
48
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
393-9
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1987
pubmed:articleTitle
[Pharmacological modifications of neuroendocrine ontogenesis. Development of receptors, nicotine and catecholamines].
pubmed:affiliation
Institut de Pharmacologie, Université de Zurich, Suisse.
pubmed:publicationType
Journal Article, English Abstract, Review, Research Support, Non-U.S. Gov't