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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1988-3-4
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pubmed:abstractText |
The effect of nebulised salbutamol on the bronchial response to nebulised histamine was studied in five wheezy infants aged 3-12 months. The response to doubling concentrations of up to 8 g/l of histamine was assessed by the change in the maximum flow at FRC (VmaxFRC), measured by flow-volume curves produced during forced expiration with a pressure jacket. The concentration of histamine required to provoke a 30% fall in VmaxFRC (PC30) was measured. All of the infants responded to low concentrations of histamine during control tests before and after nebulised saline (mean PC30 1.07 and 0.51 g/l). On a separate day there was a similar response to histamine before salbutamol (PC30 0.57 g/l), but after salbutamol the response was completely abolished up to the maximum concentration of histamine in all subjects (PC30 greater than 8 g/l). Thus wheezy infants have highly effective beta 2 adrenoceptors in intrathoracic airways.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/2829374-1167065,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2829374-1190821,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2829374-3433245,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2829374-3433246,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2829374-3730643,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2829374-3979434,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2829374-4058952,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2829374-5572789,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2829374-6105834,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2829374-6124199,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2829374-6144287,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2829374-617315,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2829374-6221700,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2829374-6275232,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2829374-6281029,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2829374-6648868,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2829374-6696507,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2829374-6867976,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2829374-7174416,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2829374-893258
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0040-6376
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
42
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
100-4
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:2829374-Albuterol,
pubmed-meshheading:2829374-Bronchi,
pubmed-meshheading:2829374-Dose-Response Relationship, Drug,
pubmed-meshheading:2829374-Drug Interactions,
pubmed-meshheading:2829374-Functional Residual Capacity,
pubmed-meshheading:2829374-Histamine,
pubmed-meshheading:2829374-Histamine Antagonists,
pubmed-meshheading:2829374-Humans,
pubmed-meshheading:2829374-Infant,
pubmed-meshheading:2829374-Nebulizers and Vaporizers,
pubmed-meshheading:2829374-Receptors, Adrenergic, beta,
pubmed-meshheading:2829374-Respiratory Sounds
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pubmed:year |
1987
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pubmed:articleTitle |
Airway responsiveness in wheezy infants: evidence for functional beta adrenergic receptors.
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pubmed:affiliation |
Department of Paediatrics and Neonatal Medicine, Royal Postgraduate Medical School, Hammersmith Hospital, London.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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