Linked Life Data

2829328

Source:http://linkedlifedata.com/resource/pubmed/id/2829328

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1988-2-29
pubmed:abstractText
Diabetes mellitus is associated with an increased incidence of hypertension and renal failure. Alterations in the renin-angiotensin system may contribute to the development of cardiovascular disorders in diabetics. This study examined diabetic associated changes in angiotensin converting enzyme (ACE). ACE activity was measured in serum, lung and kidney tissue derived from normoglycemic or 3-48 day streptozotocin (STZ)-induced diabetic rats. Serum and tissue ACE activity were not altered 3 days post STZ treatment. Serum ACE activity significantly increased in the diabetic group relative to controls, beginning 12 days post STZ treatment. Insulin treatment for 10 days partially normalized serum ACE activity. Therefore, STZ-induced diabetes produced significant changes in ACE activity that are partially corrected by insulin treatment.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0034-5164
pubmed:author
pubmed:issnType
Print
pubmed:volume
58
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
27-39
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed:year
1987
pubmed:articleTitle
The effect of streptozotocin-induced diabetes and insulin treatment on angiotensin converting enzyme activity.
pubmed:affiliation
Department of Pharamcology, Marshall University School of Medicine, Huntington, WV 25704.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't