Linked Life Data

2829260

Source:http://linkedlifedata.com/resource/pubmed/id/2829260

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1988-3-24
pubmed:abstractText
We studied beta-adrenergic receptor binding, using 125I-cyanopindolol as the ligand, in the leukocyte membranes of depressed patients, schizophrenic patients, and normal control subjects during a drug-free period. We also determined plasma cortisol levels and dexamethasone suppression in these subjects. The maximum number of beta-adrenergic receptor sites (Bmax) was significantly lower in depressed patients than in normal control subjects. Nonsuppressors on the dexamethasone suppression test tended to have a decreased Bmax in comparison to suppressors. There was no significant difference in the Kd between any of the groups. These results indicate that decreased beta-adrenergic receptor responsiveness in the leukocytes of depressed patients is probably due to a decrease in the number of beta-adrenergic receptor sites.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0165-1781
pubmed:author
pubmed:issnType
Print
pubmed:volume
22
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
265-73
pubmed:dateRevised
2008-4-17
pubmed:meshHeading
pubmed:year
1987
pubmed:articleTitle
Decreased beta-adrenergic receptors in the leukocytes of depressed patients.
pubmed:affiliation
Department of Psychiatry, College of Medicine, University of Illinois, Chicago.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.