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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6151
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pubmed:dateCreated |
1988-3-2
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pubmed:abstractText |
The T-cell surface glycoprotein, CD4 (T4), acts as the cellular receptor for human immunodeficiency virus, type 1 (HIV-1), the first member of the family of viruses that cause acquired immunodeficiency syndrome. HIV recognition of CD4 is probably mediated through the virus envelope glycoprotein (gp120) as shown by co-immunoprecipitation of CD4 and gp120 (ref.5) and by experiments using recombinant gp120 as a binding probe. Here we demonstrate that recombinant soluble CD4(rsT4) purified from the conditioned medium of a stably transfected Chinese hamster ovary cell line is a potent inhibitor of both virus replication and virus-induced cell fusion (syncytium formation). These results suggest that rsT4 is sufficient to bind HIV, and that it represents a potential anti-viral therapy for HIV infection.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Differentiation...,
http://linkedlifedata.com/resource/pubmed/chemical/HIV Envelope Protein gp120,
http://linkedlifedata.com/resource/pubmed/chemical/Peptide Fragments,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, HIV,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Virus,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Fusion Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Retroviridae Proteins
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0028-0836
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
7
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pubmed:volume |
331
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pubmed:owner |
NLM
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pubmed:authorsComplete |
N
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pubmed:pagination |
76-8
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:2829022-Animals,
pubmed-meshheading:2829022-Antigens, Differentiation, T-Lymphocyte,
pubmed-meshheading:2829022-Binding, Competitive,
pubmed-meshheading:2829022-Cell Fusion,
pubmed-meshheading:2829022-Cell Line,
pubmed-meshheading:2829022-Cricetinae,
pubmed-meshheading:2829022-Cricetulus,
pubmed-meshheading:2829022-Female,
pubmed-meshheading:2829022-HIV,
pubmed-meshheading:2829022-HIV Envelope Protein gp120,
pubmed-meshheading:2829022-Ovary,
pubmed-meshheading:2829022-Peptide Fragments,
pubmed-meshheading:2829022-Receptors, HIV,
pubmed-meshheading:2829022-Receptors, Virus,
pubmed-meshheading:2829022-Recombinant Fusion Proteins,
pubmed-meshheading:2829022-Recombinant Proteins,
pubmed-meshheading:2829022-Retroviridae Proteins,
pubmed-meshheading:2829022-Solubility,
pubmed-meshheading:2829022-Virus Replication
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pubmed:year |
1988
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pubmed:articleTitle |
HIV infection is blocked in vitro by recombinant soluble CD4.
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pubmed:affiliation |
Biogen Research Corporation, Cambridge, Massachusetts 02142.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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