|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:dateCreated |
1988-3-18
|
|
pubmed:abstractText |
Since pain and depression are influenced by opioids and antidepressants, it was of interest to explore their interaction with common CNS receptors. A method for binding site selectivity was used to evaluate antidepressant specificities in inhibiting mu versus delta opioid binding. With the very specific opioid probes used, DAGO and DPDPE, a wide range of antidepressant selectivities was found. These may represent different modes of interaction between mu and delta opioid sites and antidepressant compounds.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antidepressive Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Enkephalin, Ala(2)-MePhe(4)-Gly(5)-,
http://linkedlifedata.com/resource/pubmed/chemical/Enkephalin, D-Penicillamine (2,5)-,
http://linkedlifedata.com/resource/pubmed/chemical/Enkephalins,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Opioid,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Opioid, delta,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Opioid, mu
|
|
pubmed:status |
MEDLINE
|
|
pubmed:issn |
1046-9516
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
75
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
351-4
|
|
pubmed:dateRevised |
2003-11-14
|
|
pubmed:meshHeading |
pubmed-meshheading:2828984-Animals,
pubmed-meshheading:2828984-Antidepressive Agents,
pubmed-meshheading:2828984-Brain,
pubmed-meshheading:2828984-Enkephalin, Ala(2)-MePhe(4)-Gly(5)-,
pubmed-meshheading:2828984-Enkephalin, D-Penicillamine (2,5)-,
pubmed-meshheading:2828984-Enkephalins,
pubmed-meshheading:2828984-Male,
pubmed-meshheading:2828984-Rats,
pubmed-meshheading:2828984-Rats, Inbred Strains,
pubmed-meshheading:2828984-Receptors, Opioid,
pubmed-meshheading:2828984-Receptors, Opioid, delta,
pubmed-meshheading:2828984-Receptors, Opioid, mu
|
|
pubmed:year |
1986
|
|
pubmed:articleTitle |
Mu/delta opioid site selectivity of some antidepressants.
|
|
pubmed:affiliation |
Department of Reproductive and Developmental Toxicology, Smith Kline and French Laboratories, Philadelphia, PA 19101.
|
|
pubmed:publicationType |
Journal Article
|
