Linked Life Data

2828770

Source:http://linkedlifedata.com/resource/pubmed/id/2828770

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1988-3-15
pubmed:abstractText
The lymphokines Interleukin 1 and 2 play essential roles in the generation of antibody to artificial and natural red cell bound antigens. Critical for the appropriate function of these lymphokines is the concentration of cAMP in responding B lymphocytes. Antigen-reactive B cells mount a strong immune response in the presence of IL-1 and IL-2 when their cAMP is high, but become unresponsive when their cAMP is low. We show here that reagents which raise cAMP concentrations (Prostaglandin E, cholera toxin, forskolin) synergize strongly with IL-1 and IL-2 in the generation of antibody. We searched for physiological signals which synergize with IL-1 and IL-2 in a similar fashion and found that peritoneal macrophages facilitate strong antibody production by B cells. This helper effect is blocked by indomethacin, suggesting that it is mediated by the cyclo-oxygenase pathway and prostaglandin. Helper T cells can also complement IL-1 and IL-2 in stimulating B cells to produce antibody. This effect is not blocked by indomethacin.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0277-6766
pubmed:author
pubmed:issnType
Print
pubmed:volume
6
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
299-308
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1987
pubmed:articleTitle
An alternate B cell activation mechanism mediated by macrophages through the release of cyclo-oxygenase pathway products and interleukin 1.
pubmed:affiliation
Memorial Sloan-Kettering Cancer Center, New York, NY 10021.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.