Linked Life Data

2828752

Source:http://linkedlifedata.com/resource/pubmed/id/2828752

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1988-3-9
pubmed:abstractText
Considerable evidence indicates that genetic determinants play a major role in the pathogenesis of a variety of human and experimentally-induced renal diseases. There are, however, no firm data to indicate which genes or types of genes can induce or promote renal disease. The recently acquired ability to make specific alterations in the genetic background of an animal affords a unique opportunity to assess the effect(s) of a given gene on the structure and function of an organ of interest. Such modifications have been carried out in the creation of transgenic mice. We examined mice transgenic for the transforming gene encoding large T-antigen which is present in the early region of simian virus 40 (SV40). Renal lesions were present in most animals. While there was some heterogeneity in the type and severity of the renal lesions observed, a majority of the older mice displayed glomerulosclerosis and/or proliferative tubular lesions which in some were associated with multiple, large tubular cysts. The appearance of these lesions in mice transgenic for a transforming gene suggests that renal expression of a gene which controls cell proliferation may be associated with the development of glomerulosclerosis and renal cysts. These findings indicate a possible role for other transforming genes, or oncogenes, in the pathogenesis of glomerulosclerosis and cystic renal disease in humans and other animal models.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0085-2538
pubmed:author
pubmed:issnType
Print
pubmed:volume
32
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
827-37
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1987
pubmed:articleTitle
Glomerulosclerosis and renal cysts in mice transgenic for the early region of SV40.
pubmed:affiliation
Division of Kidney, Urologic, and Hematologic Diseases, National Institute of Diabetes, Digestive and Kidney Disease, Bethesda, Maryland.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.