Linked Life Data

2828346

Source:http://linkedlifedata.com/resource/pubmed/id/2828346

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pubmed-article:2828346pubmed:abstractTextThe complete cDNA for human tissue-type plasminogen activator (t-PA) was cloned and sequenced. A mutant was constructed by using in vitro site-specific mutagenesis to delete the region encoding the growth factor domain (amino acids 51-87 inclusive). Normal and mutant t-PA species were produced using two mammalian expression systems (in human HeLa cells and mouse C127 cells). The clearance of mutant and normal t-PA from plasma was examined in vivo using a guinea pig model. Mutant t-PA derived from HeLa or C127 cells was cleared much more slowly than the cognate normal t-PA. The potential role of the growth factor domain in the recognition of t-PA by the hepatic clearance mechanism is discussed.lld:pubmed
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pubmed-article:2828346pubmed:articleTitleA tissue-type plasminogen activator mutant with prolonged clearance in vivo. Effect of removal of the growth factor domain.lld:pubmed
pubmed-article:2828346pubmed:affiliationBeecham Pharmaceuticals Research Division, Biosciences Research Centre, Epsom, Surrey, United Kingdom.lld:pubmed
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