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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1988-1-27
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pubmed:abstractText |
Glomerular lesions were successfully induced in rats by a single footpad injection of synthetic analogues of nephritogenoside [alpha-Glc-(1----6)-alpha-Glc-(1-NHCO-Asn, and -Gln)]. Characteristic morphological changes of these glomerular lesions are (1) focal glomerulonephritis (FGN) and (2) the appearance of myeloid bodies in the epithelial cells of the podocytes. FGN produced by a single injection of the synthetic analogues of nephritogenoside may provide an experimental animal model of this potentially diffuse disease, since morphological changes in the early stage of sclerosing glomerulonephritis (end-stage kidney) induced by a single footpad injection of natural nephritogenoside are often identical to those of FGN.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
0028-2766
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
47
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
101-8
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pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:2827042-Animals,
pubmed-meshheading:2827042-Asparagine,
pubmed-meshheading:2827042-Cells, Cultured,
pubmed-meshheading:2827042-Disease Models, Animal,
pubmed-meshheading:2827042-Fluorescent Antibody Technique,
pubmed-meshheading:2827042-Glomerulonephritis,
pubmed-meshheading:2827042-Glutamine,
pubmed-meshheading:2827042-Glycopeptides,
pubmed-meshheading:2827042-Humans,
pubmed-meshheading:2827042-Inclusion Bodies,
pubmed-meshheading:2827042-Kidney Glomerulus,
pubmed-meshheading:2827042-Kidney Tubules, Proximal,
pubmed-meshheading:2827042-Male,
pubmed-meshheading:2827042-Rats,
pubmed-meshheading:2827042-Rats, Inbred Strains,
pubmed-meshheading:2827042-Trisaccharides
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pubmed:year |
1987
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pubmed:articleTitle |
Nephritogenic glycoprotein. XII. Focal glomerulonephritis with myeloid bodies produced in rats by synthetic analogues of the glycopeptide, nephritogenoside.
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pubmed:affiliation |
Clinical Research Institute, National Medical Center, Tokyo, Japan.
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pubmed:publicationType |
Journal Article
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