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pubmed-article:2826122pubmed:abstractTextAsbestos fibers in vitro produce lipid peroxidation in rat lung microsomes. Butylated hydroxytoluene prevented this peroxidation. Ascorbate in low concentrations enhanced peroxidation of lipids but inhibited it at concentrations above 4 mmole/liter so that it partially protected membrane lipids from peroxidation produced by asbestos fibers. Reduced glutathione added to microsomes gave increased peroxidation at increased concentrations up to 20 mmol/liter. At 40 mmol/liter peroxidation was prevented. Glutathione had no obvious effect on the level of peroxidation produced by asbestos fibers. The 105,000g supernatant cell fraction added either with or without glutathione gave a decrease in the amount of lipid peroxidation produced by asbestos fibers. The protective action of these reducing agents suggests a possible use as prophylactic agents against the harmful effects of inhaled asbestos.lld:pubmed
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pubmed-article:2826122pubmed:articleTitleCrocidolite-induced lipid peroxidation. II. Role of antioxidants.lld:pubmed
pubmed-article:2826122pubmed:affiliationNational Centre for Occupational Health, Johannesburg, South Africa.lld:pubmed
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