| pubmed-article:2826056 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2826056 | lifeskim:mentions | umls-concept:C0450101 | lld:lifeskim |
| pubmed-article:2826056 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:2826056 | lifeskim:mentions | umls-concept:C0026473 | lld:lifeskim |
| pubmed-article:2826056 | lifeskim:mentions | umls-concept:C1709694 | lld:lifeskim |
| pubmed-article:2826056 | lifeskim:mentions | umls-concept:C0449450 | lld:lifeskim |
| pubmed-article:2826056 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:2826056 | pubmed:dateCreated | 1988-1-25 | lld:pubmed |
| pubmed-article:2826056 | pubmed:abstractText | To determine whether viral antigens associated with infected cells were processed for presentation to T cells, we cultured human blood mononuclear cells (MNC) from varicella-zoster virus (VZV) immune donors with VZV-infected fibroblasts of known HLA type which had been fixed in 0.05% glutaraldehyde. After 7-8 days of culture thymidine uptake by T4+ cells exceeded that of T8+ cells. Stimulated cells were depleted of adherent cells and restimulated with VZV-infected fibroblasts from donors matched or unmatched with the responder for HLA type in the presence or absence of fresh adherent cells. Proliferation of the VZV-specific blasts required the presence of adherent cells matched with the responder lymphocytes for HLA-DR; conversely, the VZV specific response was not restricted by the MHC of the fibroblasts used in the restimulation assay. Preincubation of the adherent cells with chloroquine inhibited the proliferative response in a dose-dependent manner. These results suggest that VZV antigens on infected cells may be processed by monocytes for presentation to T cells. | lld:pubmed |
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| pubmed-article:2826056 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2826056 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2826056 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:2826056 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2826056 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:2826056 | pubmed:issn | 0009-9104 | lld:pubmed |
| pubmed-article:2826056 | pubmed:author | pubmed-author:HaywardA RAR | lld:pubmed |
| pubmed-article:2826056 | pubmed:author | pubmed-author:LevinM JMJ | lld:pubmed |
| pubmed-article:2826056 | pubmed:author | pubmed-author:PontesilliOO | lld:pubmed |
| pubmed-article:2826056 | pubmed:author | pubmed-author:CarotenutoPP | lld:pubmed |
| pubmed-article:2826056 | pubmed:author | pubmed-author:SuezDD | lld:pubmed |
| pubmed-article:2826056 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2826056 | pubmed:volume | 70 | lld:pubmed |
| pubmed-article:2826056 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2826056 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2826056 | pubmed:pagination | 127-35 | lld:pubmed |
| pubmed-article:2826056 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:2826056 | pubmed:meshHeading | pubmed-meshheading:2826056-... | lld:pubmed |
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| pubmed-article:2826056 | pubmed:meshHeading | pubmed-meshheading:2826056-... | lld:pubmed |
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| pubmed-article:2826056 | pubmed:meshHeading | pubmed-meshheading:2826056-... | lld:pubmed |
| pubmed-article:2826056 | pubmed:year | 1987 | lld:pubmed |
| pubmed-article:2826056 | pubmed:articleTitle | Processing and presentation of cell-associated varicella-zoster virus antigens by human monocytes. | lld:pubmed |
| pubmed-article:2826056 | pubmed:affiliation | Barbara Davis Center for Childhood Diabetes, (University of Colorado School of Medicine), Denver 80262. | lld:pubmed |
| pubmed-article:2826056 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2826056 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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