|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
1
|
|
pubmed:dateCreated |
1988-1-25
|
|
pubmed:abstractText |
To determine whether viral antigens associated with infected cells were processed for presentation to T cells, we cultured human blood mononuclear cells (MNC) from varicella-zoster virus (VZV) immune donors with VZV-infected fibroblasts of known HLA type which had been fixed in 0.05% glutaraldehyde. After 7-8 days of culture thymidine uptake by T4+ cells exceeded that of T8+ cells. Stimulated cells were depleted of adherent cells and restimulated with VZV-infected fibroblasts from donors matched or unmatched with the responder for HLA type in the presence or absence of fresh adherent cells. Proliferation of the VZV-specific blasts required the presence of adherent cells matched with the responder lymphocytes for HLA-DR; conversely, the VZV specific response was not restricted by the MHC of the fibroblasts used in the restimulation assay. Preincubation of the adherent cells with chloroquine inhibited the proliferative response in a dose-dependent manner. These results suggest that VZV antigens on infected cells may be processed by monocytes for presentation to T cells.
|
|
pubmed:grant |
|
|
pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/2826056-14200088,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2826056-198487,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2826056-2580908,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2826056-2988834,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2826056-3005647,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2826056-3872335,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2826056-3930653,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2826056-4179068,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2826056-4370611,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2826056-6090042,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2826056-6164929,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2826056-6169778,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2826056-6172474,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2826056-6184238,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2826056-6193218,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2826056-6203969,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2826056-6242349,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2826056-6245148,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2826056-6279341,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2826056-6333686,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2826056-6415484,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2826056-6457863,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2826056-6490855,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2826056-762611,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2826056-78901,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2826056-95205
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Oct
|
|
pubmed:issn |
0009-9104
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
70
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
127-35
|
|
pubmed:dateRevised |
2009-11-18
|
|
pubmed:meshHeading |
pubmed-meshheading:2826056-Adult,
pubmed-meshheading:2826056-Antigen-Presenting Cells,
pubmed-meshheading:2826056-Antigens, Surface,
pubmed-meshheading:2826056-Antigens, Viral,
pubmed-meshheading:2826056-Cell Division,
pubmed-meshheading:2826056-Chloroquine,
pubmed-meshheading:2826056-Fibroblasts,
pubmed-meshheading:2826056-HLA Antigens,
pubmed-meshheading:2826056-Herpesvirus 3, Human,
pubmed-meshheading:2826056-Humans,
pubmed-meshheading:2826056-Lymphocyte Activation,
pubmed-meshheading:2826056-Monocytes
|
|
pubmed:year |
1987
|
|
pubmed:articleTitle |
Processing and presentation of cell-associated varicella-zoster virus antigens by human monocytes.
|
|
pubmed:affiliation |
Barbara Davis Center for Childhood Diabetes, (University of Colorado School of Medicine), Denver 80262.
|
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
|
