rdf:type |
|
lifeskim:mentions |
|
pubmed:issue |
1
|
pubmed:dateCreated |
1988-1-12
|
pubmed:abstractText |
Synthetic human tumor hypercalcemic factor (1-34, hHF) was compared with parathyroid hormone (human sequence, 1-34; hPTH) for vasorelaxant activity in isolated rabbit renal artery segments. The hHF exhibited a potent (IC50 = 1.3 x 10(-9) M) and profound (98%) relaxation which was significantly greater in magnitude than that obtained for hPTH (IC50 = 4.5 x 10(-9) M; maximal relaxation = 78%). The relaxations to both peptides were concentration-dependent and not associated with changes in cyclic AMP levels. These results demonstrate a parathyroid hormone-like response, independent of adenylate cyclase activation, in isolated renal arteries. Renal vasodilation may be important for the effects on renal function shared by these two peptides.
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Nov
|
pubmed:issn |
0006-291X
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:day |
30
|
pubmed:volume |
149
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
227-32
|
pubmed:dateRevised |
2006-11-15
|
pubmed:meshHeading |
pubmed-meshheading:2825699-Animals,
pubmed-meshheading:2825699-Cyclic AMP,
pubmed-meshheading:2825699-Forskolin,
pubmed-meshheading:2825699-Humans,
pubmed-meshheading:2825699-Male,
pubmed-meshheading:2825699-Methoxamine,
pubmed-meshheading:2825699-Muscle Contraction,
pubmed-meshheading:2825699-Muscle Relaxation,
pubmed-meshheading:2825699-Neoplasm Proteins,
pubmed-meshheading:2825699-Parathyroid Hormone,
pubmed-meshheading:2825699-Parathyroid Hormone-Related Protein,
pubmed-meshheading:2825699-Peptide Fragments,
pubmed-meshheading:2825699-Proteins,
pubmed-meshheading:2825699-Rabbits,
pubmed-meshheading:2825699-Renal Artery
|
pubmed:year |
1987
|
pubmed:articleTitle |
Synthetic tumor-derived human hypercalcemic factor exhibits parathyroid hormone-like vasorelaxation in renal arteries.
|
pubmed:affiliation |
Department of Pharmacology, Merck Sharp & Dohme Research Laboratories, West Point, PA 19486.
|
pubmed:publicationType |
Journal Article,
Comparative Study
|