Linked Life Data

2825515

Source:http://linkedlifedata.com/resource/pubmed/id/2825515

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
12
pubmed:dateCreated
1988-1-20
pubmed:abstractText
Mucosal cytomegalic inclusion disease (CID) is a serious complication in acquired immune deficiency syndrome (AIDS) that usually is associated with disseminated cytomegalovirus (CMV) infection, and leads progressively to death in many patients. Early diagnosis may improve the chances of responding to specific antiviral therapy. We analyzed retrospectively the diagnostic evaluations of 26 AIDS patients with histopathologically confirmed CID infections and 19 AIDS or AIDS-related complex patients without CMV infections. The groups were similar demographically and clinically. Characteristic CMV inclusion bodies were found on antemortem biopsy in 92% of patients, including 80% for rectal biopsy alone. The specificity of the viral inclusions for CMV was established using an immunohistological technique. Rectal culture for virus isolation was much less sensitive (30%) than biopsy. Urine cultures were positive more frequently (39%) than were rectal cultures, but were less specific. Furthermore, the presence of immunoglobulin G anti-CMV was nonspecific and the presence of immunoglobulin anti-CMV was both insensitive and nonspecific. We conclude that mucosal biopsy is a rapid and reliable means of detecting cytomegalovirus infections, and is an indispensible part of the evaluation for this disease.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0002-9270
pubmed:author
pubmed:issnType
Print
pubmed:volume
82
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1264-70
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1987
pubmed:articleTitle
Evaluation of diagnostic criteria for mucosal cytomegalic inclusion disease in the acquired immune deficiency syndrome.
pubmed:affiliation
Department of Medicine, St. Luke's-Roosevelt Hospital Center, College of Physicians and Surgeons, Columbia University, New York.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't