pubmed-article:2824448 | rdf:type | pubmed:Citation | lld:pubmed |
pubmed-article:2824448 | lifeskim:mentions | umls-concept:C0014834 | lld:lifeskim |
pubmed-article:2824448 | lifeskim:mentions | umls-concept:C0204727 | lld:lifeskim |
pubmed-article:2824448 | lifeskim:mentions | umls-concept:C0205409 | lld:lifeskim |
pubmed-article:2824448 | lifeskim:mentions | umls-concept:C0596988 | lld:lifeskim |
pubmed-article:2824448 | lifeskim:mentions | umls-concept:C0070043 | lld:lifeskim |
pubmed-article:2824448 | lifeskim:mentions | umls-concept:C1880022 | lld:lifeskim |
pubmed-article:2824448 | pubmed:issue | 12 | lld:pubmed |
pubmed-article:2824448 | pubmed:dateCreated | 1988-1-14 | lld:pubmed |
pubmed-article:2824448 | pubmed:abstractText | Escherichia coli mutants conditionally defective in the conversion of pantothenate to coenzyme A were isolated and characterized. The gene was designated coaA and localized between argEH and rpoB near min 90 of the chromosome. The coaA15(Ts) mutation caused a temperature-sensitive growth phenotype and temperature-dependent inactivation of pantothenate kinase activity assayed both in vivo and in vitro. At 30 degrees C, coaA15(Ts) extracts contained less than 20% of the wild-type pantothenate kinase activity; the kinase had near normal kinetic constants for the substrates ATP and pantothenate and was inhibited by coenzyme A to the same degree as the wild-type enzyme. These data define the coaA gene as the structural gene for pantothenate kinase. | lld:pubmed |
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pubmed-article:2824448 | pubmed:language | eng | lld:pubmed |
pubmed-article:2824448 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:2824448 | pubmed:citationSubset | IM | lld:pubmed |
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pubmed-article:2824448 | pubmed:status | MEDLINE | lld:pubmed |
pubmed-article:2824448 | pubmed:month | Dec | lld:pubmed |
pubmed-article:2824448 | pubmed:issn | 0021-9193 | lld:pubmed |
pubmed-article:2824448 | pubmed:author | pubmed-author:RockC OCO | lld:pubmed |
pubmed-article:2824448 | pubmed:author | pubmed-author:VallariD SDS | lld:pubmed |
pubmed-article:2824448 | pubmed:issnType | Print | lld:pubmed |
pubmed-article:2824448 | pubmed:volume | 169 | lld:pubmed |
pubmed-article:2824448 | pubmed:owner | NLM | lld:pubmed |
pubmed-article:2824448 | pubmed:authorsComplete | Y | lld:pubmed |
pubmed-article:2824448 | pubmed:pagination | 5795-800 | lld:pubmed |
pubmed-article:2824448 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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pubmed-article:2824448 | pubmed:year | 1987 | lld:pubmed |
pubmed-article:2824448 | pubmed:articleTitle | Isolation and characterization of temperature-sensitive pantothenate kinase (coaA) mutants of Escherichia coli. | lld:pubmed |
pubmed-article:2824448 | pubmed:affiliation | Department of Biochemistry, St. Jude Children's Research Hospital, Memphis, Tennessee 38101. | lld:pubmed |
pubmed-article:2824448 | pubmed:publicationType | Journal Article | lld:pubmed |
pubmed-article:2824448 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
pubmed-article:2824448 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
entrez-gene:948479 | entrezgene:pubmed | pubmed-article:2824448 | lld:entrezgene |
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