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pubmed-article:2823744pubmed:abstractTextA cytogenetic study was performed on short-term cultures from fresh surgical specimens obtained from 41 patients with soft-tissue sarcomas of various histologic origins. The results demonstrated that myxoid liposarcomas (five tumors) were associated with a specific translocation between chromosomes 12 and 16 and that synovial sarcomas (six tumors) were associated with a specific translocation between the X chromosome and chromosome 18. These chromosomal data have been used to differentiate myxoid liposarcoma from other myxoid tumors exhibiting a non-characteristic histologic picture, as well as to ascertain the diagnosis of synovial sarcoma in undifferentiated soft-tissue sarcomas. The results to date indicate that identification of specific chromosomal changes in sarcomas may provide a new diagnostic criterion for these tumors and possibly improve prognostication with regard to survival and response to treatment.lld:pubmed
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pubmed-article:2823744pubmed:articleTitleChromosomal changes in soft-tissue sarcomas. A new diagnostic parameter.lld:pubmed
pubmed-article:2823744pubmed:affiliationDepartment of Surgical Oncology, Roswell Park Memorial Institute, Buffalo, NY 14263.lld:pubmed
pubmed-article:2823744pubmed:publicationTypeJournal Articlelld:pubmed
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