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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
11
|
| pubmed:dateCreated |
1987-11-27
|
| pubmed:abstractText |
A cytogenetic study was performed on short-term cultures from fresh surgical specimens obtained from 41 patients with soft-tissue sarcomas of various histologic origins. The results demonstrated that myxoid liposarcomas (five tumors) were associated with a specific translocation between chromosomes 12 and 16 and that synovial sarcomas (six tumors) were associated with a specific translocation between the X chromosome and chromosome 18. These chromosomal data have been used to differentiate myxoid liposarcoma from other myxoid tumors exhibiting a non-characteristic histologic picture, as well as to ascertain the diagnosis of synovial sarcoma in undifferentiated soft-tissue sarcomas. The results to date indicate that identification of specific chromosomal changes in sarcomas may provide a new diagnostic criterion for these tumors and possibly improve prognostication with regard to survival and response to treatment.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Nov
|
| pubmed:issn |
0004-0010
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
122
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1257-60
|
| pubmed:dateRevised |
2004-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:2823744-Adult,
pubmed-meshheading:2823744-Aged,
pubmed-meshheading:2823744-Chromosome Aberrations,
pubmed-meshheading:2823744-Chromosomes, Human, Pair 12,
pubmed-meshheading:2823744-Chromosomes, Human, Pair 16,
pubmed-meshheading:2823744-Chromosomes, Human, Pair 18,
pubmed-meshheading:2823744-Female,
pubmed-meshheading:2823744-Humans,
pubmed-meshheading:2823744-Lipoma,
pubmed-meshheading:2823744-Liposarcoma,
pubmed-meshheading:2823744-Male,
pubmed-meshheading:2823744-Middle Aged,
pubmed-meshheading:2823744-Ring Chromosomes,
pubmed-meshheading:2823744-Sarcoma,
pubmed-meshheading:2823744-Sarcoma, Synovial,
pubmed-meshheading:2823744-Soft Tissue Neoplasms,
pubmed-meshheading:2823744-Translocation, Genetic,
pubmed-meshheading:2823744-X Chromosome
|
| pubmed:year |
1987
|
| pubmed:articleTitle |
Chromosomal changes in soft-tissue sarcomas. A new diagnostic parameter.
|
| pubmed:affiliation |
Department of Surgical Oncology, Roswell Park Memorial Institute, Buffalo, NY 14263.
|
| pubmed:publicationType |
Journal Article
|