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rdf:type |
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lifeskim:mentions |
umls-concept:C0006556,
umls-concept:C0009013,
umls-concept:C0009392,
umls-concept:C0014467,
umls-concept:C0021759,
umls-concept:C0024297,
umls-concept:C0025914,
umls-concept:C0026809,
umls-concept:C0086418,
umls-concept:C0204727,
umls-concept:C0205409,
umls-concept:C0439849,
umls-concept:C0441655,
umls-concept:C0679058,
umls-concept:C1521761,
umls-concept:C1547699,
umls-concept:C1880022,
umls-concept:C2700640
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pubmed:issue |
21
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pubmed:dateCreated |
1987-12-9
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pubmed:abstractText |
Conditioned medium from the Con A-treated mouse helper T-cell clone Ly1+2-/9 contains activities that enhance the production of IgA by mouse B cells and induce human cord blood cells to form eosinophil colonies. We have isolated a cDNA sequence that expresses IgA-enhancing factor and eosinophil colony-stimulating factor activities from a cDNA library prepared from activated Ly1+2-/9 cells. Based on homology with the mouse cDNA sequence, a human cDNA sequence coding for an interleukin with IgA-enhancing factor and eosinophil colony-stimulating factor activities was isolated from a cDNA library prepared from a human T-cell clone stimulated with anti-T3 antibody and phorbol 12-myristate 13-acetate. DNA sequence analyses revealed that mouse and human cDNA clones encode proteins of 133 and 134 amino acids, respectively, that are identical to cDNA clones encoding the T-cell replacing factor I and B-cell growth factor II activities. These results establish that a single cDNA clone encodes a protein that acts as a growth and differentiation factor for both B cells and eosinophils.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/2823259-2419430,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2823259-2934482,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2823259-3005865,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2823259-3016727,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2823259-3024009,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2823259-3024129,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2823259-3083412,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2823259-3484551,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2823259-3516005,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2823259-3925454,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2823259-3932582,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2823259-3933529,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2823259-518835,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2823259-6246368,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2823259-6300662,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2823259-6322187,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2823259-6432933,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2823259-6785749
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Colony-Stimulating Factors,
http://linkedlifedata.com/resource/pubmed/chemical/DNA,
http://linkedlifedata.com/resource/pubmed/chemical/DNA Restriction Enzymes,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-5,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukins,
http://linkedlifedata.com/resource/pubmed/chemical/Lymphokines,
http://linkedlifedata.com/resource/pubmed/chemical/Prostatic Secretory Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/beta-microseminoprotein,
http://linkedlifedata.com/resource/pubmed/chemical/immunoglobulin-binding factors
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
84
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pubmed:owner |
NLM
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pubmed:authorsComplete |
N
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pubmed:pagination |
7388-92
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:2823259-Amino Acid Sequence,
pubmed-meshheading:2823259-Animals,
pubmed-meshheading:2823259-Bone Marrow Cells,
pubmed-meshheading:2823259-Cell Line,
pubmed-meshheading:2823259-Cloning, Molecular,
pubmed-meshheading:2823259-Colony-Stimulating Factors,
pubmed-meshheading:2823259-DNA,
pubmed-meshheading:2823259-DNA Restriction Enzymes,
pubmed-meshheading:2823259-Eosinophils,
pubmed-meshheading:2823259-Humans,
pubmed-meshheading:2823259-Interleukin-5,
pubmed-meshheading:2823259-Interleukins,
pubmed-meshheading:2823259-Lymphokines,
pubmed-meshheading:2823259-Mice,
pubmed-meshheading:2823259-Molecular Sequence Data,
pubmed-meshheading:2823259-Prostatic Secretory Proteins,
pubmed-meshheading:2823259-RNA, Messenger,
pubmed-meshheading:2823259-T-Lymphocytes
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pubmed:year |
1987
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pubmed:articleTitle |
Isolation and characterization of lymphokine cDNA clones encoding mouse and human IgA-enhancing factor and eosinophil colony-stimulating factor activities: relationship to interleukin 5.
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pubmed:affiliation |
Department of Molecular Biology, DNAX Research Institute of Molecular and Cellular Biology, Palo Alto, CA 94034-1104.
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pubmed:publicationType |
Journal Article
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