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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
3
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pubmed:dateCreated |
1987-12-16
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pubmed:abstractText |
In Sprague Dawley rats, six days after subtotal nephrectomy, serum 1,25(OH)2D3 concentration was diminished (59.8 +/- 17.5 pg/ml vs. 121 +/- 48; P less than 0.01). Despite low circulating 1,25(OH)2D3 levels, maximal specific binding capacity for 1,25(OH)2D3 in parathyroid glands was diminished (Nmax 87.5 fmol/mg protein and 3.52 fmol/mg DNA vs. 143 fmol/mg protein and 4.75 fmol/mg DNA, respectively). There was no change of KD, apparent molecular size (sucrose density gradient) and DNA binding affinity (DNA cellulose chromatography) pointing to intactness of the receptor. Since 1,25(OH)2D3 is a potent negative feedback signal for parathyroids, the data are potentially relevant for the genesis of secondary renal hyperparathyroidism.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0085-2538
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
32
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
350-3
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:2822993-Animals,
pubmed-meshheading:2822993-Calcitriol,
pubmed-meshheading:2822993-Centrifugation, Density Gradient,
pubmed-meshheading:2822993-Chromatography, Affinity,
pubmed-meshheading:2822993-DNA,
pubmed-meshheading:2822993-Male,
pubmed-meshheading:2822993-Organ Size,
pubmed-meshheading:2822993-Parathyroid Glands,
pubmed-meshheading:2822993-Rats,
pubmed-meshheading:2822993-Rats, Inbred Strains,
pubmed-meshheading:2822993-Receptors, Calcitriol,
pubmed-meshheading:2822993-Receptors, Steroid,
pubmed-meshheading:2822993-Uremia
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pubmed:year |
1987
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pubmed:articleTitle |
Diminished parathyroid 1,25(OH)2D3 receptors in experimental uremia.
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pubmed:affiliation |
Department of Internal Medicine, University of Heidelberg, Federal Republic of Germany.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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