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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
11
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pubmed:dateCreated |
1987-11-30
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pubmed:databankReference |
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pubmed:abstractText |
A papillomavirus was isolated from the epithelial layer of a cutaneous fibropapilloma on a Swedish reindeer (Rangifer tarandus). Reindeer papillomavirus (RPV) is morphologically indistinguishable from other papillomaviruses, but the restriction enzyme cleavage pattern of its genome is different. No sequence homology was detected between RPV DNA and the DNAs of bovine papillomavirus type 1 (BPV-1) and avian papillomavirus when hybridization was performed under stringent conditions. However, the RPV genome hybridized to the genome of the European elk papillomavirus and the deer papillomavirus under stringent conditions. A physical map of the RPV genome was constructed, and selected regions of the genome, covering the open translational reading frame (ORF) E5 and part of the E1 and L1 ORFs, were studied by nucleotide sequence analysis. The results made it possible to align the RPV genome with the genome of BPV-1. The E5 ORF of RPV has the potential to encode a 44-amino-acid, exceptionally hydrophobic polypeptide which is very similar to the E5 polypeptides of BPV-1 and deer and European elk papillomaviruses. RPV is oncogenic for hamsters and transforms C127 mouse cells in vitro. Several virus-specific mRNAs were detected in RPV-transformed C127 cells.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/2822949-1195397,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2822949-13501906,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2822949-210957,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2822949-213876,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2822949-2989533,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2822949-2993669,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2822949-2997076,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2822949-2999614,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2822949-3001335,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2822949-3003234,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2822949-3006073,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2822949-3006336,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2822949-3014660,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2822949-3034730,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2822949-4291934,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2822949-4300248,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2822949-6088809,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2822949-6159641,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2822949-6246368,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2822949-6250043,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2822949-6251381,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2822949-6266142,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2822949-6279309,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2822949-6283148,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2822949-6289064,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2822949-6289124,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2822949-6293191,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2822949-6312094,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2822949-6320328,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2822949-6321162,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2822949-6546423,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2822949-728982,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2822949-881736,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2822949-942051
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0022-538X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
61
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3394-400
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:2822949-Amino Acid Sequence,
pubmed-meshheading:2822949-Animals,
pubmed-meshheading:2822949-Base Sequence,
pubmed-meshheading:2822949-Cell Transformation, Neoplastic,
pubmed-meshheading:2822949-Cloning, Molecular,
pubmed-meshheading:2822949-Cricetinae,
pubmed-meshheading:2822949-DNA, Viral,
pubmed-meshheading:2822949-DNA Restriction Enzymes,
pubmed-meshheading:2822949-Genes, Viral,
pubmed-meshheading:2822949-Mesocricetus,
pubmed-meshheading:2822949-Mice,
pubmed-meshheading:2822949-Molecular Sequence Data,
pubmed-meshheading:2822949-Nucleic Acid Hybridization,
pubmed-meshheading:2822949-Papillomaviridae,
pubmed-meshheading:2822949-Protein Biosynthesis,
pubmed-meshheading:2822949-Reindeer,
pubmed-meshheading:2822949-Viral Proteins
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pubmed:year |
1987
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pubmed:articleTitle |
Reindeer papillomavirus transforming properties correlate with a highly conserved E5 region.
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pubmed:affiliation |
Department of Veterinary Microbiology, Biomedical Center, Uppsala, Sweden.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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