Linked Life Data

282269

Source:http://linkedlifedata.com/resource/pubmed/id/282269

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1979-3-24
pubmed:abstractText
Various N-substituted polymethylene diamides were synthesized and tested for their potency to induce erythroid differentiation in murine erythroleukemia cells. N,N,N',N'-tetramethyl-1.6-hexane-dicarboxamide (IIc) was the most potent inducer among 15 compounds tested. The effectiveness of this compound was similar to that of hexamethylene bisacetamide (HMBA). HMBA has a different amide linkage order from that of IIc. HMBA and IIc at a concentration of 5 mM had similar effects on the cell growth rate and induced a similar frequency of benzidine-positive cells. However, hemoglobin production was 1.5 times more effective with IIc. Polymethylene diester, diamide, dihydrazide and dianilide had no effect on the induction of hemoglobin synthesis. The N-alkylated amide group appears to be required for induction of differentiation in murine erythroleukemia cells.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0020-7136
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
23
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
119-22
pubmed:dateRevised
2007-7-24
pubmed:meshHeading
pubmed:year
1979
pubmed:articleTitle
Induction of erythroid differentiation in murine erythroleukemia cells by N-substituted polymethylene diamides.
pubmed:publicationType
Journal Article