Linked Life Data

2822649

Source:http://linkedlifedata.com/resource/pubmed/id/2822649

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1987-12-1
pubmed:abstractText
The antibacterial activity of LY146032 was greatly potentiated in the presence of calcium ions. In the presence of a physiological concentration of calcium (ca 100 mg/l: 2.5 mM) the new compound was more active than vancomycin or teicoplanin against a selection of clinical isolates of staphylococci and streptococci. The requirement for calcium could not be satisfied by magnesium. The activity of LY146032 varied when tested in different culture media, including batches of Mueller-Hinton agar from different manufacturers. The highest minimum inhibitory concentrations of LY146032 were observed in tests on Iso-Sensitest agar, which contains little calcium. Supplementation of Iso-Sensitest agar with increasing concentrations of calcium caused a proportionate fall in the MIC of LY146032. Saponin-lysed horse blood; incubation in a CO2-rich atmosphere; and an increase in the bacterial inoculum from 10(3) to 10(6) cfu/spot had little effect on the activity of LY146032 in the presence or absence of calcium.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0305-7453
pubmed:author
pubmed:issnType
Print
pubmed:volume
20
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
213-21
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1987
pubmed:articleTitle
The effect of cultural conditions on the activity of LY146032 against staphylococci and streptococci.
pubmed:affiliation
Department of Microbiology, University Hospital, Queen's Medical Centre, Nottingham, U.K.
pubmed:publicationType
Journal Article