Linked Life Data

2822525

Source:http://linkedlifedata.com/resource/pubmed/id/2822525

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1987-12-17
pubmed:abstractText
Dispersed, superfused goldfish anterior pituitary cell columns were stimulated with pulses of salmon angiotensin I (sAI), human angiotensin I (hAI), and human angiotensin II (hAII). Human AII stimulated the greatest release of ACTH. The dose-response curves for hAI and sAI were similar and revealed that hAI and sAI were about one-tenth as potent as hAII in stimulating ACTH release. In mammals, AI must be converted to AII in order to stimulate ACTH release. In goldfish, the angiotensin-converting enzyme inhibitor captopril, which inhibits the conversion of AI to AII, was not able to block sAI-stimulated ACTH release. This finding suggests that the angiotensin receptor of the goldfish corticotrope is less discriminating than that of the mammalian corticotrope and recognizes both AI and AII. This hypothesis was supported by the observation that sarcosine analogs of AII, which block AII-stimulated ACTH release in mammals, failed to block hAII-stimulated ACTH release in goldfish. Saralasin showed negligible, [Sar1,Thr8]-AII slight, and [Sar1, Ile8]-AII moderate, intrinsic ACTH-releasing activity. These findings suggest that the ACTH-releasing activity of angiotensin appeared early in the evolution of the vertebrate pituitary.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0016-6480
pubmed:author
pubmed:issnType
Print
pubmed:volume
68
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
19-27
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1987
pubmed:articleTitle
Stimulation by angiotensins I and II of ACTH release from goldfish pituitary cell columns.
pubmed:affiliation
Department of Anatomy, Faculty of Health Sciences, University of Ottawa, Ontario, Canada.
pubmed:publicationType
Journal Article, In Vitro, Research Support, Non-U.S. Gov't