rdf:type |
|
lifeskim:mentions |
umls-concept:C0006556,
umls-concept:C0031686,
umls-concept:C0162801,
umls-concept:C0204727,
umls-concept:C0205409,
umls-concept:C0600499,
umls-concept:C0679058,
umls-concept:C1334043,
umls-concept:C1522642,
umls-concept:C1547699,
umls-concept:C1704708,
umls-concept:C2697616,
umls-concept:C2700640
|
pubmed:issue |
2
|
pubmed:dateCreated |
1987-12-9
|
pubmed:databankReference |
|
pubmed:abstractText |
A 1.5 kb clone containing the full-length coding sequence of a type-1 protein phosphatase catalytic subunit has been isolated from a rabbit skeletal muscle cDNA library constructed in lambda gt10. The protein sequence deduced from the cDNA contains 311 residues and has a molecular mass of 35.4 kDa. A single mRNA species at 1.6 kb was visualized by Northern blotting. The type-1 protein phosphatase was strikingly homologous to protein phosphatase 2A, 49% of the amino acids between residues 11 and 280 being identical. The first 10 and last 31 residues were dissimilar. Residues 1-101 of the type-1 protein phosphatase also showed 21% sequence identity with a region of mammalian alkaline phosphatases.
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Nov
|
pubmed:issn |
0014-5793
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:day |
2
|
pubmed:volume |
223
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
340-6
|
pubmed:dateRevised |
2007-11-15
|
pubmed:meshHeading |
pubmed-meshheading:2822491-Amino Acid Sequence,
pubmed-meshheading:2822491-Animals,
pubmed-meshheading:2822491-Base Sequence,
pubmed-meshheading:2822491-Cloning, Molecular,
pubmed-meshheading:2822491-DNA,
pubmed-meshheading:2822491-Molecular Sequence Data,
pubmed-meshheading:2822491-Muscles,
pubmed-meshheading:2822491-Peptide Fragments,
pubmed-meshheading:2822491-Phosphoprotein Phosphatases,
pubmed-meshheading:2822491-Protein Phosphatase 2,
pubmed-meshheading:2822491-RNA, Messenger,
pubmed-meshheading:2822491-Rabbits,
pubmed-meshheading:2822491-Sequence Homology, Nucleic Acid
|
pubmed:year |
1987
|
pubmed:articleTitle |
Isolation and sequence analysis of a cDNA clone encoding a type-1 protein phosphatase catalytic subunit: homology with protein phosphatase 2A.
|
pubmed:affiliation |
Department of Biochemistry, University of Dundee, Scotland.
|
pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|