Linked Life Data

2821950

Source:http://linkedlifedata.com/resource/pubmed/id/2821950

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1987-11-20
pubmed:abstractText
The effect that hypertension may have on plasma, atrial ANF levels and on isolate rat renal glomeruli ANF receptors was investigated. Different models of renal hypertension were studied: 1-K, 1-C (BP = 177 +/- 7 mmHg), 2-K, 1-C (BP = 158 +/- 3 mmHg) and their respective controls (BP = 100 +/- 2 mmHg). At this stage of hypertension (two weeks) plasma ANF was 56 +/- 9 and 25 +/- 2 pg/ml in 2-K, 1-C and controls respectively and 124 +/- 22 vs 35 +/- 4 pg/ml in 1-K, 1-C and controls. Atrial ANF content was lower in hypertensive animals. A marked up-regulation of the glomerular ANF receptor density was observed in 2-K, 1-C animals. In the right kidney we found 840 fmol/mg protein and 540 fmol/mg protein, and in the left 1,070 fmol/mg protein against 608 fmol/mg protein in 2-K, 1-C and control animals respectively. No change was observed in glomerular ANF receptor density in 1-K, 1-C animals. We have then demonstrated that glomerular ANF receptor density is higher in 2-K, 1-C hypertensive than in normotensive animals. It could be possible, however, that the receptor density may change during the evolution of high blood pressure in the models of experimental hypertension currently studied.
pubmed:language
fre
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0003-9683
pubmed:author
pubmed:issnType
Print
pubmed:volume
80
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
966-9
pubmed:dateRevised
2009-2-13
pubmed:meshHeading
pubmed:year
1987
pubmed:articleTitle
[ANF receptors at the glomerular level in reno-vascular hypertension in rats].
pubmed:affiliation
Laboratoire d'Hypertension expérimentale et des peptides vasoactifs, Institut de Recherches Cliniques de Montréal, Québec, Canada.
pubmed:publicationType
Journal Article, English Abstract, Research Support, Non-U.S. Gov't