Linked Life Data

2821407

Source:http://linkedlifedata.com/resource/pubmed/id/2821407

Statements in which the resource exists.
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pubmed-article:2821407pubmed:abstractTextProtein kinase C is important in the transduction of signals generated at the plasma membrane. The physiological activators of protein kinase C are diacylglycerols, and the tumour-promoting phorbol esters, such as 12-O-tetradecanoyl-phorbol-14 acetate (TPA), constitute another group of specific activators. Many cellular substrates for phosphorylation by protein kinase C have been described, but proteins that directly control transcription in response to protein kinase C activation are yet to be identified. TPA treatment leads to induction of various proto-oncogenes, growth factor genes, and genes encoding secreted proteases. In addition. TPA increases the activity of viral enhancer elements. To identify trans-acting factors that mediate the transcriptional response to TPA we chose the simian virus 40 (SV40) enhancer as a model, because it is known to be composed of several discrete cis-acting elements which are recognized by multiple transacting factors. We report here that the SV40 enhancer contains at least four different TPA responsive elements whose activity is dependent on cell-type. The induction response is likely to involve at least two distinct post-translational steps which modulate the activity of the proteins that recognize these elements.lld:pubmed
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pubmed-article:2821407pubmed:volume329lld:pubmed
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pubmed-article:2821407pubmed:dateRevised2008-11-21lld:pubmed
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pubmed-article:2821407pubmed:articleTitleMultiple cis- and trans-acting elements mediate the transcriptional response to phorbol esters.lld:pubmed
pubmed-article:2821407pubmed:affiliationDepartment of Pharmacology, School of Medicine, University of California, San Diego, La Jolla 92093.lld:pubmed
pubmed-article:2821407pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:2821407pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed
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