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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
6140
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pubmed:dateCreated |
1987-11-18
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pubmed:abstractText |
Protein kinase C is important in the transduction of signals generated at the plasma membrane. The physiological activators of protein kinase C are diacylglycerols, and the tumour-promoting phorbol esters, such as 12-O-tetradecanoyl-phorbol-14 acetate (TPA), constitute another group of specific activators. Many cellular substrates for phosphorylation by protein kinase C have been described, but proteins that directly control transcription in response to protein kinase C activation are yet to be identified. TPA treatment leads to induction of various proto-oncogenes, growth factor genes, and genes encoding secreted proteases. In addition. TPA increases the activity of viral enhancer elements. To identify trans-acting factors that mediate the transcriptional response to TPA we chose the simian virus 40 (SV40) enhancer as a model, because it is known to be composed of several discrete cis-acting elements which are recognized by multiple transacting factors. We report here that the SV40 enhancer contains at least four different TPA responsive elements whose activity is dependent on cell-type. The induction response is likely to involve at least two distinct post-translational steps which modulate the activity of the proteins that recognize these elements.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:issn |
0028-0836
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
329
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
648-51
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:2821407-Base Sequence,
pubmed-meshheading:2821407-Cell Line,
pubmed-meshheading:2821407-Deoxyribonuclease I,
pubmed-meshheading:2821407-Enhancer Elements, Genetic,
pubmed-meshheading:2821407-Gene Expression Regulation,
pubmed-meshheading:2821407-Humans,
pubmed-meshheading:2821407-Mutation,
pubmed-meshheading:2821407-Phorbol Esters,
pubmed-meshheading:2821407-Protein Kinase C,
pubmed-meshheading:2821407-Proto-Oncogenes,
pubmed-meshheading:2821407-Simian virus 40,
pubmed-meshheading:2821407-Tetradecanoylphorbol Acetate,
pubmed-meshheading:2821407-Transcription, Genetic
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pubmed:articleTitle |
Multiple cis- and trans-acting elements mediate the transcriptional response to phorbol esters.
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pubmed:affiliation |
Department of Pharmacology, School of Medicine, University of California, San Diego, La Jolla 92093.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
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