Linked Life Data

2820896

Source:http://linkedlifedata.com/resource/pubmed/id/2820896

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PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1987-11-19
pubmed:abstractText
Our study focused on the relationship between lymphocyte H/S ratios and antiviral antibodies. We have concluded a longitudinal survey of 29 clinically definite MS patients for 8 months seeking a possible correlation among clinical modifications, fluctuations of T-cell subsets and antiviral antibody titers. For this purpose in each patient the following parameters were recorded monthly:--clinical history and neurological examination;--blood T-cell subpopulation as defined by monoclonal antibodies of the OKT series;--serum antibody titers against measles, herpes simplex type 1 and 2, HTLV-1 viruses. All these data were compared with the different MS subgroups as defined by clinical course: stable, relapsing, progressive. We found that constantly normal OKT4+/OKT8+ ratios correlate with a stable clinical course; that highly fluctuating ratios parallel clinical exacerbation; that constantly high ratios are associated with a chronic-progressive course. These results are discussed with special reference to the correlation between OKT8+ lymphocyte percentages and anti-HTLV-1 antibodies, since this last virus has recently been claimed to be of pathogenetic importance in MS.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0392-0461
pubmed:author
pubmed:issnType
Print
pubmed:volume
Suppl 6
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
53-6
pubmed:dateRevised
2005-11-17
pubmed:meshHeading
pubmed:year
1987
pubmed:articleTitle
Longitudinal survey of T-lymphocytes and viral antibodies in MS patients.
pubmed:affiliation
Centro Studi Sclerosi Multipla, Gallarate.
pubmed:publicationType
Journal Article