Linked Life Data

2819363

Source:http://linkedlifedata.com/resource/pubmed/id/2819363

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
742
pubmed:dateCreated
1990-1-8
pubmed:abstractText
Transplanted C3H mouse mammary tumours were given single doses of X irradiation in air or oxygen at 1 atmosphere (atm) with or without anaesthesia of the recipient mice by ketamine and diazepam. The radiation response to single doses of 25 Gy was determined in terms of the time taken to reach 3.5 times the treatment volume. Under all conditions there was more growth delay in tumours irradiated in pure oxygen than in air. In both air and oxygen, the radiation response for anaesthetized animals tended to fall below the level for non-anaesthetized ones when only 10 min had elapsed after the administration of anaesthesia. After 25 min, the response in air was back to the level for the non-anaesthetized animals but the oxygen group now showed significant sensitization compared with the oxygen without anaesthetic group. After 40 min, the air group now showed slight sensitization and the oxygen group still showed significant sensitization by the anaesthetic. These results demonstrate the importance of the time interval between anaesthesia and irradiation of mouse tumours.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0007-1285
pubmed:author
pubmed:issnType
Print
pubmed:volume
62
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
932-5
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1989
pubmed:articleTitle
Variation of tumour radiosensitivity with time after anaesthetic.
pubmed:affiliation
Richard Dimbleby Department of Cancer Research, United Medical School, St Thomas' Hospital, London.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't