Linked Life Data

2818618

Source:http://linkedlifedata.com/resource/pubmed/id/2818618

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
19
pubmed:dateCreated
1989-11-28
pubmed:abstractText
The effects of streptozotocin-induced diabetes and fasting on hepatic cytochrome P-450 enzymes in sexually mature male rats were studied by immunochemical techniques and enzyme assays. The level of cytochrome P-450ac (an acetone/ethanol inducible form), 65 pmol/mg microsomal protein in control rats, increased 4- to 5-fold in diabetic rats and 3- and 5-fold in fasting rats. In contrast, P-450 UT-A (a male specific form) decreased drastically from 295 pmol/mg in the control group to about 10% of this value in diabetic rats and to 50% in fasting rats. P-450 PCN-E (a 16 alpha-cyanopregnenolone/dexamethasone inducible form), on the other hand, decreased from 151 pmol/mg to 38% in diabetic rats and increased 2-fold in fasting rats. These changes were also reflected in catalytic activities using N-nitrosodimethylamine, benzphetamine, and erythromycin as substrates. Slight changes in cytochromes P-450 UT-F, P-450 UT-I and P-450 PB-C were also observed under these conditions, but the biological significance is not known. These results suggest that different mechanisms exist for the regulation of the expression of cytochrome P-450 enzymes in diabetic and fasting rats.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0006-2952
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
38
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
3179-84
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1989
pubmed:articleTitle
Similarities and differences in the regulation of hepatic cytochrome P-450 enzymes by diabetes and fasting in male rats.
pubmed:affiliation
Department of Biochemistry, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark 07103.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.