Linked Life Data

2817612

Source:http://linkedlifedata.com/resource/pubmed/id/2817612

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1989-12-11
pubmed:abstractText
Lobar pulmonary arteries demonstrate increased production of extracellular matrix components in response to hypertension, but biosynthetic changes in lobar veins have not been described. We report here that steady-state levels of mRNAs for tropoelastin and type I procollagen in proximal lobar veins were decreased in calves with hypoxic pulmonary hypertension relative to levels detected in veins from normotensive animals. In contrast, transcript levels were elevated in lobar arteries from hypertensive calves. Histologically, medial thickening and hypertrophy were apparent in distal lobar arteries from pulmonary hypertensive calves, but at this level no structural changes were observed in veins. These results indicate that the synthetic response to hypoxic pulmonary hypertension is complex, with different alterations in the expression of extracellular matrix components in the pulmonary arterial and venous circulations.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0003-0805
pubmed:author
pubmed:issnType
Print
pubmed:volume
140
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1455-7
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1989
pubmed:articleTitle
Response of lobar vessels to hypoxic pulmonary hypertension.
pubmed:affiliation
Department of Medicine, Jewish Hospital, Washington University Medical Center, St. Louis, Missouri 63110.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't