Linked Life Data

2815596

Source:http://linkedlifedata.com/resource/pubmed/id/2815596

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1989-12-18
pubmed:abstractText
The complete nucleotide sequence of one representative rat genomic unit flanked on both sides with RAL elements, which have structural features specific to retroviral LTRs (1), was determined. The total unit was about 7.5 kbp long, and there was a partial homology to known retroviral sequences in gag, pol, and env regions. The sequence also contained minus- and plus-strand primer binding sites, thereby indicating a retroviral nature in replication. Transcription of the sequence was extensive in tumor cells and was strongly correlated with the state of methylation within 5' LTRs, which were highly methylated in the normal but not in the tumor state. In functional assays with bacterial chloramphenicol acetyltransferase constructs containing a series of deleted LTRs, there seemed to be both positive and negative cis-acting effector sequences.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0920-8569
pubmed:author
pubmed:issnType
Print
pubmed:volume
3
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
69-83
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1989
pubmed:articleTitle
Isolation and characterization of a family of rat endogenous retroviral sequences.
pubmed:affiliation
Department of Biochemistry, Kyushu University, Fukuoka, Japan.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't