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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
4
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pubmed:dateCreated |
1989-11-29
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pubmed:abstractText |
We studied two patients with hypogammaglobulinaemia, three with selective IgA deficiency, and four with selective extreme IgM deficiency for T-cell abnormalities in the circulating blood. Most patients had altered CD4+ helper/inducer and CD8+ suppressor/cytotoxic T-cell subsets, and an elevated percentage of HLA-DR+ and interleukin 2 (IL-2) receptor+ antigens on lymphocytes. One patient with the selective IgA deficiency had an absence of CD4+ T cells in blood. The lymphocytes of eight patients showed a diminished proliferative response and deficient IL-2 production in response to stimulation with phytohaemagglutinin or concanavalin A. The three patients with selective IgM deficiency were found to have a defective T-cell abnormality in IgM synthesis by B cells. It is interesting that CD8+ T cells of the two patients with IgM deficiency demonstrated suppressor cell function for IgM synthesis by the normal B and T cells.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0300-9475
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
30
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
419-24
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pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:2814365-Agammaglobulinemia,
pubmed-meshheading:2814365-Antibodies, Monoclonal,
pubmed-meshheading:2814365-B-Lymphocytes,
pubmed-meshheading:2814365-Child,
pubmed-meshheading:2814365-Child, Preschool,
pubmed-meshheading:2814365-Dysgammaglobulinemia,
pubmed-meshheading:2814365-Humans,
pubmed-meshheading:2814365-IgA Deficiency,
pubmed-meshheading:2814365-Immunoglobulin M,
pubmed-meshheading:2814365-Interleukin-2,
pubmed-meshheading:2814365-Phytohemagglutinins,
pubmed-meshheading:2814365-T-Lymphocytes
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pubmed:year |
1989
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pubmed:articleTitle |
T-cell abnormalities in antibody deficiency syndromes.
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pubmed:affiliation |
Department of Clinical Immunology, King Saud University, College of Medicine, Abha, Saudi Arabia.
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pubmed:publicationType |
Journal Article
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