Linked Life Data

2810274

Source:http://linkedlifedata.com/resource/pubmed/id/2810274

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
9
pubmed:dateCreated
1989-12-7
pubmed:abstractText
The contribution of the spleen to the arthritogenic and immune response to type II collagen in mice was measured by a series of in vitro and in vivo experiments. Negligible antibody production and proliferative responses to collagen were measured in the spleen from immunized mice, compared to lymph node and peripheral blood. Further, splenectomized mice were found to be susceptible to collagen induced arthritis with a similar disease incidence to sham operated controls. There were no major differences in the sera antibody responses or the delayed-type hypersensitivity responses to collagen between the splenectomized and control mice. The primary regulation of the response to type II collagen in collagen induced arthritis was apparently independent of the spleen cell population.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0315-162X
pubmed:author
pubmed:issnType
Print
pubmed:volume
16
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1192-6
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1989
pubmed:articleTitle
Type II collagen induced arthritis in mice. V. The role of the spleen cell response in the immune and arthritogenic reaction to type II collagen.
pubmed:affiliation
Ayerst Laboratories Research, Inc., Princeton NJ.
pubmed:publicationType
Journal Article, In Vitro