| pubmed-article:2809510 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2809510 | lifeskim:mentions | umls-concept:C0021753 | lld:lifeskim |
| pubmed-article:2809510 | lifeskim:mentions | umls-concept:C0021760 | lld:lifeskim |
| pubmed-article:2809510 | lifeskim:mentions | umls-concept:C0003241 | lld:lifeskim |
| pubmed-article:2809510 | lifeskim:mentions | umls-concept:C0004610 | lld:lifeskim |
| pubmed-article:2809510 | lifeskim:mentions | umls-concept:C1456820 | lld:lifeskim |
| pubmed-article:2809510 | lifeskim:mentions | umls-concept:C0700364 | lld:lifeskim |
| pubmed-article:2809510 | lifeskim:mentions | umls-concept:C0392756 | lld:lifeskim |
| pubmed-article:2809510 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:2809510 | pubmed:dateCreated | 1989-12-11 | lld:pubmed |
| pubmed-article:2809510 | pubmed:abstractText | Cytokines secreted in response to invading micro-organisms are important mediators of detrimental hemodynamic and metabolic changes in the host. To test whether cachectin/TNF plays a role in triggering release of other cytokines in the setting of infection, anesthetized baboons were passively immunized against systemic cachectin/TNF before infusion of a LD100 dose of live Escherichia coli. Bacteremia led to significant increases in circulating levels of cachectin/TNF, IL-1 beta, and IL-6. Although bacterial endotoxin/lipopolysaccharide is a potent stimulus for the synthesis and release of IL-1 and IL-6 in vitro, specific neutralization of cachectin/TNF in vivo with mAb pretreatment significantly attenuated both the IL-1 beta and the IL-6 responses despite fulminant overwhelming bacteremia. These data suggest that cachectin/TNF is essential for the initiation or amplification of IL-1 and IL-6 release during lethal gram-negative septic shock syndrome. | lld:pubmed |
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| pubmed-article:2809510 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:2809510 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:2809510 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2809510 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:2809510 | pubmed:issn | 0022-1007 | lld:pubmed |
| pubmed-article:2809510 | pubmed:author | pubmed-author:LowryS FSF | lld:pubmed |
| pubmed-article:2809510 | pubmed:author | pubmed-author:CAPM PMP | lld:pubmed |
| pubmed-article:2809510 | pubmed:author | pubmed-author:AllisonA CAC | lld:pubmed |
| pubmed-article:2809510 | pubmed:author | pubmed-author:MoldawerL LLL | lld:pubmed |
| pubmed-article:2809510 | pubmed:author | pubmed-author:KennelJ HJH | lld:pubmed |
| pubmed-article:2809510 | pubmed:author | pubmed-author:LeeA TAT | lld:pubmed |
| pubmed-article:2809510 | pubmed:author | pubmed-author:TraderJ EJE | lld:pubmed |
| pubmed-article:2809510 | pubmed:author | pubmed-author:FontTT | lld:pubmed |
| pubmed-article:2809510 | pubmed:author | pubmed-author:HesseD GDG | lld:pubmed |
| pubmed-article:2809510 | pubmed:author | pubmed-author:ManogueK BKB | lld:pubmed |
| pubmed-article:2809510 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2809510 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:2809510 | pubmed:volume | 170 | lld:pubmed |
| pubmed-article:2809510 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2809510 | pubmed:authorsComplete | N | lld:pubmed |
| pubmed-article:2809510 | pubmed:pagination | 1627-33 | lld:pubmed |
| pubmed-article:2809510 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:2809510 | pubmed:year | 1989 | lld:pubmed |
| pubmed-article:2809510 | pubmed:articleTitle | Antibodies to cachectin/tumor necrosis factor reduce interleukin 1 beta and interleukin 6 appearance during lethal bacteremia. | lld:pubmed |
| pubmed-article:2809510 | pubmed:affiliation | Department of Surgery, New York Hospital, Cornell Medical Center, New York 10021. | lld:pubmed |
| pubmed-article:2809510 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2809510 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:2809510 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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